Uncomplicated urinary tract infection in women is one of the most common reasons for presenting in ambulatory care and causes high rates of antibiotic prescription. Treatment approaches to reduce antibiotic use were tested in several randomised controlled trials.
In the meta-analysis of individual patient data, we will estimate the effect of the therapeutic strategies to reduce antibiotic consumption compared to immediate antibiotic treatment. Furthermore, we aim to identify prognostic factors and moderators of different courses of disease to develop a clinical prediction model for general practice.
Studies included in this project compare and contrast different treatment strategies (analgesics, phytotherapeutics, delayed antibiotic prescriptions and placebo) with immediate antibiotic treatment. Individual patient data allow the differentiated analysis of effects of non-antibiotic strategies compared to antibiotic treatment. Furthermore, differences between particular treatment strategies can be compared. In total, IPD of nine trials meeting the inclusion criteria could have been extracted and are currently analysed.
The project is scheduled to be two years in duration and is an international cooperation of institutes of general practice in Germany (Würzburg, Göttingen), Belgium (Ghent), Great Britain (Southampton, Bristol), Norway (Oslo) as well as the Department of Medical Statistics (Göttingen, Germany) and the Department of Clinical Microbiology (Umea, Sweden), the Department of Clinical Pharmacology (Ghent, Belgium), Center for Health Sciences and Primary Care (Utrecht, Netherlands), Applied Health Research Centre (Toronto, Canada), and the Institute for Infectious Diseases (Bern, Switzerland).
National and international institutes of general practice and primary care
- University Hospital Würzburg (Institute of General Practice), Germany
- University Medical Center Göttingen (Department of General Practice/Family Medicine), Germany
- Ghent University (Department of Family Medicine and Primary Health Care), Belgium
- University of Southampton, Academic Unit of Primary Care, UK
- University of Southampton, Primary Care & Population Sciences, UK
- University of Bristol, Centre for Academic Primary Care, UK
- University of Oslo, Institute of Health and Society, Norway
- University Medical Centre Utrecht, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, Netherlands
- University of Toronto, Applied Health Research Centre (AHRC), St. Michael’s Hospital, Canada
National and international institutes of statistics, clinical pharmacology and microbiology
- University Medical Center Göttingen (Department of Medical Statistics), Germany
- Ghent University (Department of Clinical Pharmacology), Belgium
- Umea University, Department of Clinical Microbiology, Sweden
- University of Bern, Institute for Infectious Diseases, Switzerland